An ongoing project at the University of Oldenburg (UOL) involves development and evaluation of prototype assistive listening devices that incorporate a microphone array into the frame of a pair of eyeglasses. The eyeglass-integrated array can be used to implement adaptive beamforming and/or Short-Time Target Cancellation (STTC) processing, which computes a ratio mask (i.e., a time-varying spectral gain) that can be used either to filter the binaural signals at the Left and Right ears or as a spectro-temporal postfilter for the adaptive beamforming. The STTC processing does not require training or a priori knowledge about the number or locations of interfering sound sources; only an assumed “look” direction is needed. Where adaptive beamforming computes a complex-valued filter-vector, the STTC processing computes a real valued time-varying spectral gain; the two approaches are compatible and our evaluation results, using both instrumental and psychoacoustic measures, indicate that their combination has an additive effect. This approach, of using an eyeglass-integrated microphone array to compute a ratio mask, should not be thought of as an attempt to supplant the ear-worn hearing aid; it is instead an approach that is additive and compatible with a traditional hearing aid and can further enhance established approaches to speech enhancement.